Pathogenicity and virulence of Rhodococcus equi in foals following intratracheal challenge
Veterinary Microbiology 56 (1997) pages 301-312
reprinted with permission of Elsevier Science
Ryuichi Wada, Masanobu Kamada, Toru Anzai, Akiko Nakanishi, Takumi Kanemaru, Shinji Takai, Shiro Tsubaki
Abstract
Twelve foals, between 27 and 83 days old, were infected with 2 strains of Rhodococcus equi by intratracheal administration. Ten of the 12 foals were inoculated with 104 - 1010 colony forming units (cfu) of ATCC 33701 strain. The other 2 foals were inoculated with 109 cfu of a plasmid-sured derivative of the ATCC 33701 (ATCC 33701P). All of the 10 foals challenged with the ATCC 33701 strain showed clinical signs of pulmonary disease within 5-13 days, such as gross lesions associated with acute bronchopneumonia and microspic lesions associated with granulomatous pneumonia. The two foals challenged with the ATCC 33701P strain showed neither clinical signs of disease nor gross lesions. Apparently, when lacking plasmid, the virulent Rhodococcus equi lost its pathogenicity. @1997 Elsevier Science B.V.
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