Products for the Treatment of F.P.T. in the Equine Neonate


HiGAMM EQUI and FOALIMMUNE

1. USDA licensed
2. Quantified IgG content
HiGamm-Equi >= 2500mg/dl
Foalimmune >= 1750mg/dl

3. Proven efficacy when dosed at 15ml/lb HiGamm-equi will produce a rise in IgG to 600mg or greater in the healthy foal.

4. 3 year frozen shelf life and free replacement for outdates or damaged bags.
5. Single universal donor source - reduces foreign protein exposure - unlike batched donor serum products which expose the recipient to more foreign proteins.

HiGamm-Equi- No other IgG product has demostrated such a large increase in foal IgG
at 24 and 48 hours after oral or intravenous administration
Mean IgG rise at 24 hours = 1042.74 mg/dl

FPT EFFICACY We've proven it! We Guarantee it!

1999 Colostrum Deprived Foal Receiving Non-Irradiated Plasma
FOAL IgG Values 24 hours and 48 hours of age
Yellow line is Mean IgG rise

product - Equine IgG = 2000 mg/dl, dose 20 ml/lb, Mean IgG rise at 24 hours = 1042.74 mg/dl

Materials, Methods and Conclusions

All foals were separated from their dams at birth and kept separated for 24 hours. Foals were not allowed to nurse during the first 24 hours. Equine IgG was administered shortly after birth. Blood samples were taken prior to the administration of Equine IgG - 0 hour, at 24 hours, and at 48 hours for IgG determination. IgG values on all samples (0 hour, 24 hour and 48 hour) were determined by Radial Immunodiffusion (VMRD) Equine RID.

The 24 and 48-hour IgG values are plotted along with the NVSL species standard (IgG = 450 ml/dl). This standard is provided by the USDA as a reference for the minimum acceptable IgG level after FPT treatment.

Results - All foals administered Hi-Gamm Equi exceed the USDA species standard, achieving a mean IgG rise to 1042 mg/dl at 24 hrs.

Conclusion – Hi-Gamm Equi provides adequate treatment for FPT and there is no significant difference in IgG rise when foals nursed colostrum after 24 hours of age. The 48-hour IgG values resulting from this trial indicate that there is no further absorption of IgG when the foal is allowed to nurse mare ’s colostrum at 24 hours of age. The mares were not milked during the first 24-hour period. This is confirmed by a comparison of the 24 hour and 48 hour IgG values. Mean 24 hour IgG = 1042mg/dl: Mean 48 hour IgG = 1074mg/dl.

ADVANTAGES WHEN PURCHASING EQUINE IgG PRODUCTS FROM LAKE IMMUNOGENICS INC.

1) Rapid administration 7 minutes* It takes only 15 minutes to thaw in warm water and then it may be administered as rapidly as any other IV fluid. As with any fluid, monitor closely during intravenous administration, because volume overload is possible.

2) No mixing with other fluids prior to administration (like Seramune & Lyphomune). No warnings about pretreatment with anti-inflammatory drugs before administration (like Seramune). No time restrictions on the rate of administration (like Seramune & Lyphomune).

3) Clear plasma - free of precipitate due to our advanced collection technique The occurrences of reactions requiring the suspension of administration are rare with an approximate incidence of 1 per 2000-3000 administrations

4) Guaranteed successful treatment of FPT when dosed properly.

5) Free replacement of outdates - 3 year shelf life.

6) Reduced shipping charges on quantity orders.

7) Lower price per gram IgG than Seramune, Lyphomune, or Polymune.

* The average administration time of 160 doses of plasma to thoroughbred foals in a 2000 field trial

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348 Berg Road Ontario, New York 14519
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